Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 8/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12964014 | 1.00 | OPRD1 (0.64) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL12836600 | 1.00 | OPRD1 (0.64) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL21226454 | 1.00 | OPRD1 (0.64) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL684700 | 0.86 | OPRM1 (0.48) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL18994809 | 0.86 | OPRM1 (0.67) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL327364 | 0.84 | OPRM1 (0.67) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL19919122 | 0.84 | OPRM1 (0.67) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL12836597 | 0.84 | OPRM1 (0.67) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL12831723 | 0.84 | OPRM1 (0.67) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL18994760 | 0.84 | OPRD1 (0.46) | OPRD1OPRM1OPRK1LMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258696-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-9849185-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof | KEMPHARM, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170143839-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydromorphone, Prodrugs, Methods of Making and Use Thereof | ALTER DOMUS (US) LLC | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143839-A1 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydromorphone, Prodrugs, Methods of Making and Use Thereof | OPRM1, OPRK1, CYP2D6 | OPRD1 7/4885OPRM1 1/4885OPRK1 2/4885 |
| US-10258696-B2 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof | OPRM1, OPRK1, CYP2D6 | OPRD1 7/4885OPRM1 1/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.