Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836597 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL12013629 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL14427319 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL327364 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL19919122 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL21859226 | 0.89 | OPRM1 (0.54) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL18878473 | 0.84 | OPRD1 (0.64) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL21226454 | 0.84 | OPRD1 (0.64) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL12836600 | 0.84 | OPRD1 (0.64) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL12964014 | 0.84 | OPRD1 (0.64) | OPRM1OPRD1OPRK1LMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10406153-B2 | Process for the preparation of benzhydrocodone hydrochloride | NORAMCO, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-10370382-B2 | Process for preparing hydromorphone and derivatives thereof | CAMBREX CHARLES CITY, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-9981978-B2 | Preparation of saturated ketone morphinan compounds by catalytic isomerisation | CAMBREX CHARLES CITY, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981979-B2 | Process for the formation of hydrocodone bitatrate | CAMBREX CHARLES CITY, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170327511-A1 | PROCESS FOR THE FORMATION OF HYDROCODONE BITATRATE | CAMBREX CHARLES CITY, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| US-20160168159-A1 | PREPARATION OF SATURATED KETONE MORPHINAN COMPOUNDS BY CATALYTIC ISOMERISATION | CAMBREX CHARLES CITY, INC. | 2016-06-16 | — | — | US | disclosed |
| US-20160168159-A1 | PREPARATION OF SATURATED KETONE MORPHINAN COMPOUNDS BY CATALYTIC ISOMERISATION | CAMBREX CHARLES CITY, INC. | 2016-06-16 | — | — | US | disclosed |
| WO-2011035276-A2 | HETEROGENEOUS RUTHENIUM METAL CATALYST FOR THE PRODUCTION OF HYDROCODONE, HYDROMORPHONE OR A DERIVATIVE THEREOF | MALLINCKRODT INC. (US) | 2011-03-24 | — | — | WO | disclosed |
| WO-2010118273-A1 | RUTHENIUM CATALYSTS FOR THE PRODUCTION OF HYDROCODONE, HYDROMORPHONE OR A DERIVATIVE THEREOF | MALLINCKRODT INC. (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168159-A1 | PREPARATION OF SATURATED KETONE MORPHINAN COMPOUNDS BY CATALYTIC ISOMERISATION | ADH1C, ADH1A, ADH5 | OPRM1 114/4885OPRD1 170/4885OPRK1 104/4885 |
| US-10370382-B2 | Process for preparing hydromorphone and derivatives thereof | CYP1A1, DHPS, CYP11B1 | OPRM1 5/4885OPRD1 9/4885OPRK1 11/4885 |
| US-20170327511-A1 | PROCESS FOR THE FORMATION OF HYDROCODONE BITATRATE | HAAO, HPD, CYP3A43 | OPRM1 168/4885OPRD1 145/4885OPRK1 75/4885 |
| US-10406153-B2 | Process for the preparation of benzhydrocodone hydrochloride | DBH, DHPS, PAH | OPRM1 74/4885OPRD1 27/4885OPRK1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.