Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.31 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18878759 | 0.82 | DRD2 (0.35) | OPRD1DRD2DRD4DRD3 | |
| SCHEMBL22058987 | 0.76 | GAA (0.48) | GAAOPRD1OPRM1DRD2DRD4 | |
| SCHEMBL18878785 | 0.74 | OPRM1 (0.65) | OPRD1OPRM1OPRK1LMNACYP3A4 | |
| SCHEMBL16454868 | 0.73 | GAA (0.76) | GAAOPRD1OPRM1OPRK1LMNA | |
| SCHEMBL22058989 | 0.71 | GAA (0.52) | GAAOPRD1OPRM1OPRK1DRD2 | |
| SCHEMBL18473472 | 0.69 | GAA (0.48) | GAAOPRD1OPRM1OPRK1CYP3A4 | |
| SCHEMBL20170647 | 0.69 | GAA (0.54) | GAAOPRD1OPRM1OPRK1LMNA | |
| SCHEMBL20170884 | 0.66 | GAA (0.48) | GAAOPRD1OPRM1OPRK1LMNA | |
| SCHEMBL13534483 | 0.64 | OPRM1 (0.81) | OPRD1OPRM1OPRK1LMNACYP3A4 | |
| SCHEMBL13100920 | 0.64 | OPRM1 (0.81) | OPRD1OPRM1OPRK1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682936-B2 | Morphan and morphinan analogues, and methods of use | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-06-20 | — | — | US | disclosed |
| US-9656961-B2 | Methods for treating depressive symptoms | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-05-23 | — | — | US | disclosed |