Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852885 | 0.89 | OPRM1 (0.81) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL13100920 | 0.89 | OPRM1 (0.81) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL13534483 | 0.89 | OPRM1 (0.81) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL14852891 | 0.83 | OPRM1 (0.60) | OPRM1OPRK1OPRD1 | |
| SCHEMBL12948089 | 0.79 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL17625328 | 0.77 | OPRM1 (0.73) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL17625329 | 0.75 | OPRM1 (0.70) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL18878753 | 0.74 | GAA (0.40) | OPRM1OPRK1OPRD1LMNACYP3A4 | |
| SCHEMBL14392904 | 0.73 | OPRM1 (0.71) | OPRM1OPRK1OPRD1LMNAPDE4D | |
| SCHEMBL12255374 | 0.72 | OPRM1 (0.74) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682936-B2 | Morphan and morphinan analogues, and methods of use | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-06-20 | — | — | US | disclosed |
| US-9656961-B2 | Methods for treating depressive symptoms | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-05-23 | — | — | US | disclosed |