Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18878753 | 0.82 | GAA (0.40) | DRD2DRD3DRD4OPRD1 | |
| SCHEMBL16454918 | 0.77 | GAA (0.54) | DRD2OPRD1 | |
| SCHEMBL18878785 | 0.69 | OPRM1 (0.65) | OPRD1 | |
| SCHEMBL18878761 | 0.65 | GAA (0.53) | OPRD1 | |
| SCHEMBL16444882 | 0.65 | GAA (0.53) | OPRD1 | |
| SCHEMBL18878843 | 0.65 | DRD2 (0.38) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL18994792 | 0.65 | OPRM1 (0.38) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL16445412 | 0.64 | GAA (0.67) | DRD2OPRD1 | |
| SCHEMBL21599894 | 0.61 | DRD2 (0.33) | DRD2DRD3DRD4 | |
| SCHEMBL5019530 | 0.60 | GAA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682936-B2 | Morphan and morphinan analogues, and methods of use | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-06-20 | — | — | US | disclosed |
| US-9656961-B2 | Methods for treating depressive symptoms | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-05-23 | — | — | US | disclosed |