Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALPI | P09923 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20644584 | 0.80 | MAPT (0.38) | SCN10AMAPTKDM4EMLKLALPL | |
| SCHEMBL20644535 | 0.79 | CACNA1H (0.40) | SCN10AMAPTKDM4EMLKLALPL | |
| SCHEMBL10299138 | 0.72 | DDAH1 (0.54) | SCN10AMAPTKDM4EMLKLALPL | |
| SCHEMBL24027323 | 0.71 | PKM (0.39) | SCN10AMAPTKDM4EMLKLALPL | |
| SCHEMBL24027318 | 0.71 | SMN1; SMN2 (0.36) | SCN10AMAPTKDM4EMLKLKMT2A | |
| SCHEMBL889358 | 0.68 | HSD17B10 (0.59) | SCN10AKDM4EMLKLNPC1ALDH1A1 | |
| SCHEMBL5988285 | 0.67 | SMN1; SMN2 (0.43) | SCN10AMAPTKDM4EMLKLKMT2A | |
| SCHEMBL19558098 | 0.66 | ALPL (0.49) | MAPTKDM4EMLKLALPLMAPK1 | |
| SCHEMBL20644416 | 0.66 | NPSR1 (0.53) | SCN10AMAPTKDM4EMLKLKMT2A | |
| SCHEMBL23479351 | 0.65 | SCN10A (0.40) | SCN10AMAPTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657057-B2 | Dipeptide and tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2017-05-23 | — | — | US | disclosed |