Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20644584 | 0.81 | MAPT (0.38) | SMN1; SMN2LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL10299138 | 0.79 | DDAH1 (0.54) | RAB9AKIF11MEN1GAAKMT2A | |
| SCHEMBL24027323 | 0.78 | PKM (0.39) | SMN1; SMN2LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL20644535 | 0.77 | CACNA1H (0.40) | SMN1; SMN2LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL5988285 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL21611999 | 0.73 | NPC1 (0.38) | SMN1; SMN2LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL19558098 | 0.72 | ALPL (0.49) | SMN1; SMN2LMNARAB9ANPC1CYP2D6 | |
| SCHEMBL21035073 | 0.71 | AAK1 (0.48) | LMNACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18888470 | 0.71 | SCN10A (0.33) | SMN1; SMN2LMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL889358 | 0.71 | HSD17B10 (0.59) | SMN1; SMN2LMNARAB9ANPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | QRFPR, P2RY11, QARS1 | SMN1; SMN2 4555/4885LMNA 4546/4885RAB9A 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.