Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921261 | 0.89 | PTGER4 (0.72) | PTGER4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5798005 | 0.87 | PTGER4 (0.57) | PTGER4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27825721 | 0.83 | MAPT (0.67) | PTGER4MAPTTP53ALDH1A1HPGD | |
| SCHEMBL10163400 | 0.81 | KDM4E (0.66) | MAPTTP53ALDH1A1HPGDKDM4E | |
| SCHEMBL13067443 | 0.81 | ALDH1A1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1921288 | 0.81 | MAPT (0.65) | PTGER4MAPTTP53ALDH1A1HPGD | |
| SCHEMBL29643271 | 0.81 | MAPT (0.65) | PTGER4MAPTTP53ALDH1A1HPGD | |
| SCHEMBL14492828 | 0.80 | PGR (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11277311 | 0.79 | MAPT (0.68) | PTGER4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14283604 | 0.78 | PTGER4 (0.49) | PTGER4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928884-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS | Bayer Pharma AG (DE) | 2017-05-24 | — | — | EP | disclosed |