Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163862 | 0.90 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL18889485 | 0.87 | PTGER4 (0.60) | PTGER4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1921261 | 0.86 | PTGER4 (0.72) | PTGER4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5794680 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL4849333 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL5797737 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL27825721 | 0.80 | MAPT (0.67) | PTGER4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL541218 | 0.78 | PTGER4 (0.59) | PTGER4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1921288 | 0.78 | MAPT (0.65) | PTGER4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29643271 | 0.78 | MAPT (0.65) | PTGER4KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006012310-A2 | CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE | GENZYME CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |