Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967791 | 0.86 | CMA1 (0.56) | TSHRALOX15CMA1CYP1A2CYP3A4 | |
| SCHEMBL7960283 | 0.84 | CMA1 (0.65) | TSHRALOX15CMA1CYP1A2CYP3A4 | |
| SCHEMBL7951731 | 0.83 | GPR84 (0.56) | TSHRALOX15CMA1S1PR2KMT2A | |
| SCHEMBL6115415 | 0.76 | CMA1 (0.56) | TSHRALOX15CMA1CYP3A4KMT2A | |
| SCHEMBL7963792 | 0.76 | CYP1A2 (0.68) | TSHRALOX15CMA1CYP1A2CYP3A4 | |
| SCHEMBL7962204 | 0.76 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL18900944 | 0.76 | MAPT (0.53) | TSHRALOX15CMA1CYP1A2CYP3A4 | |
| SCHEMBL18900946 | 0.74 | GPR84 (0.59) | KMT2AMEN1MAPT | |
| SCHEMBL8695759 | 0.72 | HPGD (0.64) | TSHRCYP1A2CYP2C9CYP2C19GLA | |
| SCHEMBL24076967 | 0.71 | ALOX15 (1.00) | TSHRALOX15CMA1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323991-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |