Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893232 | 0.91 | HTR6 (0.60) | HTR6SLC6A4LMNAKMT2AUSP2 | |
| SCHEMBL5937271 | 0.91 | HTR6 (0.57) | HTR6SLC6A4LMNAKMT2AAPP | |
| Hydrochloric Acid SCHEMBL5705102 | 0.89 | SLC6A4 (0.57) | HTR6SLC6A4LMNAKMT2AAPP | |
| Hydrochloric Acid SCHEMBL30611185 | 0.89 | SLC6A4 (0.57) | HTR6SLC6A4LMNAKMT2AAPP | |
| SCHEMBL17067795 | 0.82 | ALDH1A1 (0.51) | SLC6A4LMNAKMT2AUSP2ALDH1A1 | |
| SCHEMBL28127883 | 0.79 | ALDH1A1 (0.49) | SLC6A4LMNAKMT2AUSP2ALDH1A1 | |
| SCHEMBL28779618 | 0.78 | RAB9A (0.48) | SLC6A4LMNAKMT2AUSP2ALDH1A1 | |
| SCHEMBL8229224 | 0.75 | SLC6A4 (0.52) | HTR6SLC6A4APPPRKCGPRKCB | |
| SCHEMBL8696576 | 0.75 | APP (0.39) | HTR6SLC6A4APP | |
| SCHEMBL12954683 | 0.75 | HTR6 (0.50) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981875-B1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| CN-101370803-B | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV | 2012-12-12 | — | — | CN | disclosed |
| US-8163765-B2 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-24 | — | — | US | disclosed |
| US-20110118291-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-19 | — | — | US | disclosed |
| US-7834025-B2 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-16 | — | — | US | disclosed |
| CN-101370803-A | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| US-20090018153-A1 | Substituted Indolyl-Alkyl-Amino-Derivatives as Inhibitors of Histone Deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018153-A1 | Substituted Indolyl-Alkyl-Amino-Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC3, HDAC2 | HTR6 668/4885SLC6A4 3609/4885LMNA 1248/4885 |
| US-20110118291-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | HTR6 668/4885SLC6A4 3662/4885LMNA 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.