Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 12/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901530 | 0.95 | SYK (0.49) | SYKHRH3CCR2MAPTKCNH2 | |
| SCHEMBL18901560 | 0.84 | GPR119 (0.54) | KDM4EALDH1A1 | |
| SCHEMBL18901609 | 0.83 | POLB (0.61) | MAPT | |
| SCHEMBL18901626 | 0.82 | PKM (0.46) | SYKCCR2KCNH2CCR5KDM4E | |
| SCHEMBL1351789 | 0.82 | SYK (0.64) | SYKHRH3 | |
| SCHEMBL1351791 | 0.82 | SYK (0.64) | SYKHRH3 | |
| SCHEMBL18901678 | 0.81 | CCR2 (0.44) | SYKCCR2KCNH2 | |
| SCHEMBL31410428 | 0.80 | HSD11B1 (0.55) | MAPTKDM4EALDH1A1 | |
| SCHEMBL18901428 | 0.80 | CCR2 (0.57) | CCR2KCNH2CCR5 | |
| SCHEMBL18901708 | 0.80 | CCR2 (0.57) | CCR2KCNH2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |