Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904081 | 0.91 | MAPT (0.41) | MAPTSMN1; SMN2RAB9ANPC1BRD9 | |
| SCHEMBL18903778 | 0.81 | CYP11B1 (0.39) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL16509575 | 0.74 | MAPT (0.63) | MAPTSMN1; SMN2RAB9AHTTALDH1A1 | |
| SCHEMBL18903780 | 0.74 | NMT1 (0.42) | MAPTSMN1; SMN2KDM4ETSHRHTT | |
| SCHEMBL18904149 | 0.72 | CYP11B2 (0.38) | MAPTSMN1; SMN2TSHRHSD17B10HTT | |
| SCHEMBL18903920 | 0.72 | MAPT (0.39) | MAPTHTTLMNA | |
| SCHEMBL16502957 | 0.71 | PDE4D (0.39) | SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL18904098 | 0.69 | L3MBTL1 (0.44) | MAPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL18903943 | 0.69 | HRH3 (0.43) | SMN1; SMN2KDM4EHTTALDH1A1LMNA | |
| SCHEMBL29699919 | 0.68 | CYP3A4 (0.50) | MAPTSMN1; SMN2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2980076-B1 | Pyrazolyl derivatives | UNIV DUNDEE (GB) | 2017-05-31 | — | — | EP | disclosed |