Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.49 |
| ▸ | ACACA | Q13085 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18909759 | 0.90 | PDE4D (0.51) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL18907641 | 0.89 | ACACB (0.53) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL16245922 | 0.89 | ACACB (0.53) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL18908179 | 0.88 | ACACB (0.48) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL18907021 | 0.87 | ACACA (0.41) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL18908171 | 0.85 | ACACB (0.44) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL18914372 | 0.85 | ACACB (0.42) | ACACBACACASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18964397 | 0.84 | ACACB (0.43) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL18907643 | 0.82 | ACACB (0.50) | ACACBACACAPDE4DPDE4APDE4B | |
| SCHEMBL29750457 | 0.81 | ACACA (0.49) | ACACBACACAPDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166584-A1 | TRIAZOLE ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. | 2017-06-15 | — | — | US | disclosed |
| US-20170166583-A1 | ESTER ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. | 2017-06-15 | — | — | US | disclosed |
| US-20170166582-A1 | PYRAZOLE ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. | 2017-06-15 | — | — | US | disclosed |
| WO-2017091617-A1 | TRIAZOLE ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166583-A1 | ESTER ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | ACACB 2/4885ACACA 1/4885PDE4D 2569/4885 |
| US-20170166582-A1 | PYRAZOLE ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, PC | ACACB 2/4885ACACA 1/4885PDE4D 2701/4885 |
| US-20170166584-A1 | TRIAZOLE ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT1 | ACACB 2/4885ACACA 1/4885PDE4D 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.