Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.45 |
| ▸ | ACACB | O00763 | 9/20 | 0.43 |
| ▸ | ACACA | Q13085 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19361575 | 0.90 | ACACB (0.44) | ACACBACACA | |
| SCHEMBL18907643 | 0.89 | ACACB (0.50) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL23969193 | 0.87 | ACACB (0.36) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL23968987 | 0.82 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18909758 | 0.80 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18908171 | 0.80 | ACACB (0.44) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL19361571 | 0.79 | POLB (0.41) | — | |
| SCHEMBL14945397 | 0.79 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL21816549 | 0.79 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL14945398 | 0.79 | ACACB (0.47) | ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912718-B2 | Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof | GILEAD APOLLO, LLC (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912718-B2 | Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof | GILEAD APOLLO, LLC (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230002405-A1 | ACC INHIBITOR AND USE THEREOF | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
| EP-3380478-B1 | ESTER ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO LLC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20200148699-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | GILEAD APOLLO, LLC | 2020-05-14 | — | — | US | disclosed |
| US-20190225623-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | NIMBUS DISCOVERY, INC. | 2019-07-25 | — | — | US | disclosed |
| US-10183951-B2 | Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof | GILEAD APOLLO, LLC (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170267690-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | J.P. LAWSON CONSULTING LLC | 2017-09-21 | — | — | US | disclosed |
| US-20170267690-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | J.P. LAWSON CONSULTING LLC | 2017-09-21 | — | — | US | disclosed |
| US-20170166583-A1 | ESTER ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. | 2017-06-15 | — | — | US | disclosed |
| US-20170166583-A1 | ESTER ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. | 2017-06-15 | — | — | US | disclosed |
| WO-2017091602-A1 | ESTER ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267690-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | ACACA, ACACB, COASY | PDE4D 3041/4885PDE4A 2610/4885PDE4B 2770/4885 |
| US-20170166583-A1 | ESTER ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | PDE4D 2569/4885PDE4A 2178/4885PDE4B 2261/4885 |
| US-11912718-B2 | Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof | ACACA, ACACB, COASY | PDE4D 3041/4885PDE4A 2610/4885PDE4B 2770/4885 |
| US-20200148699-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | ACACA, ACACB, COASY | PDE4D 3041/4885PDE4A 2610/4885PDE4B 2770/4885 |
| US-20230002405-A1 | ACC INHIBITOR AND USE THEREOF | ACACA, ACACB, ACAT1 | PDE4D 3219/4885PDE4A 3024/4885PDE4B 3057/4885 |
| US-10183951-B2 | Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof | ACACA, ACACB, COASY | PDE4D 3041/4885PDE4A 2610/4885PDE4B 2770/4885 |
| US-20190225623-A1 | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF | ACACA, ACACB, COASY | PDE4D 3041/4885PDE4A 2610/4885PDE4B 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.