Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747473 | 0.90 | HSD11B1 (1.00) | HSD11B1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL10942013 | 0.81 | HSD11B1 (0.76) | HSD11B1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL2748146 | 0.81 | HSD11B1 (0.82) | HSD11B1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL2746814 | 0.80 | HSD11B1 (1.00) | HSD11B1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL21303108 | 0.80 | HSD11B1 (0.52) | HSD11B1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18905854 | 0.79 | HSD11B1 (0.71) | HSD11B1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL2747350 | 0.79 | HSD11B1 (0.83) | HSD11B1 | |
| SCHEMBL9226272 | 0.79 | HSD11B1 (0.71) | HSD11B1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL14006043 | 0.78 | HSD11B1 (0.83) | HSD11B1ALDH1A1LMNAHPGD | |
| SCHEMBL14077015 | 0.77 | HSD11B1 (0.58) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152262-A1 | VINYLOGOUS THIOESTER COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152262-A1 | VINYLOGOUS THIOESTER COMPOUNDS AND METHODS OF USE | ACOT7, LYPLA2, PPT1 | HSD11B1 401/4885ALDH1A1 1113/4885NPC1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.