Sugi Predict

Sugi Predict / Compounds / SCHEMBL1891444

SCHEMBL1891444

SCHEMBL1891444

CCOC(=O)n1nc(NC(=O)c2ccc(OC3CCN(C)CC3)cc2[N+](=O)[O-])c2c1CCN(C(=O)OC(C)(C)C)C2

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 3/20 0.36
▸ GCK P35557 2/20 0.35
▸ HCAR2 Q8TDS4 1/20 0.35
▸ HCAR1 Q9BXC0 1/20 0.35
▸ INSR P06213 1/20 0.34
▸ IGF1R P08069 1/20 0.34
▸ ALK Q9UM73 1/20 0.34
▸ HRH3 Q9Y5N1 1/20 0.34
▸ TP53 P04637 2/20 0.33
▸ PRMT5 O14744 1/20 0.33
▸ WDR77 Q9BQA1 1/20 0.33
▸ F12 P00748 2/20 0.33
▸ HPGDS O60760 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1890828 0.89 AKR1B10 (0.40) TP53
SCHEMBL1890065 0.86 SIRT6 (0.40) —
SCHEMBL1898452 0.85 TP53 (0.34) GPR119GCKTP53F12
SCHEMBL2679514 0.85 INSR (0.40) HCAR2HCAR1INSRIGF1RALK
Hydrochloric Acid SCHEMBL2679512 0.84 INSR (0.39) HCAR2HCAR1INSRIGF1RALK
SCHEMBL1890661 0.84 MAPT (0.35) TP53F12
SCHEMBL2454525 0.83 ALDH1A1 (0.44) TP53F12
SCHEMBL1883184 0.83 IGF1R (0.39) HCAR2HCAR1INSRIGF1RALK
SCHEMBL1891508 0.81 MTOR (0.40) —
SCHEMBL1892408 0.81 F12 (0.32) TP53F12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed
EP-1968976-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.r.l. (IT) 2008-09-17 — — EP disclosed
WO-2007068619-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 GPR119 941/4885GCK 419/4885HCAR2 4379/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 GPR119 941/4885GCK 419/4885HCAR2 4379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.