Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325661 | 0.93 | TDP1 (0.48) | TDP1MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL7404593 | 0.83 | TDP1 (0.56) | TDP1MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL4272023 | 0.83 | TDP1 (0.56) | TDP1MEN1KMT2AMAPTCYP1A2 | |
| Bicarbonate SCHEMBL28922932 | 0.79 | TDP1 (0.56) | TDP1MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL10797201 | 0.79 | KDM4E (0.47) | TDP1MEN1KMT2ACYP1A2NR4A1 | |
| SCHEMBL7443128 | 0.78 | MTNR1A (0.50) | TDP1MEN1KMT2ACYP1A2CTNNB1 | |
| SCHEMBL6411524 | 0.77 | CYP1A2 (0.52) | TDP1MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL27980048 | 0.77 | ALDH1A1 (0.40) | TDP1MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL10750285 | 0.77 | MAOB (0.58) | TDP1MEN1KMT2ACYP1A2ACP3 | |
| SCHEMBL29176451 | 0.77 | HTT (0.50) | TDP1MEN1KMT2ACYP1A2CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9896530-B2 | Copolymer, coloring material dispersion, ink, and ink store container | RICOH COMPANY, LTD. (JP) | 2018-02-20 | — | — | US | disclosed |
| US-20170158794-A1 | COPOLYMER, COLORING MATERIAL DISPERSION, INK, AND INK STORE CONTAINER | RICOH COMPANY, LTD. (JP) | 2017-06-08 | — | — | US | disclosed |