Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18919163 | 1.00 | PIKFYVE (0.51) | PIKFYVEGSK3BSIGMAR1KMT2AACHE | |
| SCHEMBL16739358 | 0.95 | PIKFYVE (0.48) | PIKFYVEGSK3BKMT2AACHEMAPT | |
| SCHEMBL18919111 | 0.95 | PIKFYVE (0.48) | PIKFYVEGSK3BKMT2AACHEMAPT | |
| SCHEMBL18919206 | 0.95 | PIKFYVE (0.49) | PIKFYVESIGMAR1KMT2AACHEMAPT | |
| SCHEMBL18919203 | 0.95 | PIKFYVE (0.49) | PIKFYVESIGMAR1KMT2AACHEMAPT | |
| SCHEMBL18919117 | 0.92 | SIGMAR1 (0.54) | PIKFYVESIGMAR1KMT2AACHEMAPT | |
| SCHEMBL18919115 | 0.92 | SIGMAR1 (0.54) | PIKFYVESIGMAR1KMT2AACHEMAPT | |
| SCHEMBL18919232 | 0.91 | DRD2 (0.49) | SIGMAR1KMT2AACHEMAPTDRD2 | |
| SCHEMBL18919231 | 0.91 | DRD2 (0.49) | SIGMAR1KMT2AACHEMAPTDRD2 | |
| SCHEMBL18919089 | 0.89 | RXFP1 (0.48) | PIKFYVEKMT2AMAPTDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157135-A1 | FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS | NOVOGEN LIMITED (AU) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170157135-A1 | FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS | TPM3, TPM4, TNNI3 | PIKFYVE 1833/4885GSK3B 764/4885SIGMAR1 2217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.