Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18919231 | 1.00 | DRD2 (0.49) | DRD2DRD3SMPD1SIGMAR1GPR183 | |
| SCHEMBL18919161 | 0.91 | PIKFYVE (0.51) | DRD2DRD3SIGMAR1POLBALDH1A1 | |
| SCHEMBL18919163 | 0.91 | PIKFYVE (0.51) | DRD2DRD3SIGMAR1POLBALDH1A1 | |
| SCHEMBL18919090 | 0.90 | MAPT (0.52) | DRD2GPR183POLBMEN1ALDH1A1 | |
| SCHEMBL18919093 | 0.90 | MAPT (0.52) | DRD2GPR183POLBMEN1ALDH1A1 | |
| SCHEMBL18919059 | 0.90 | SIGMAR1 (0.54) | DRD2DRD3SIGMAR1ALDH1A1LMNA | |
| SCHEMBL18919060 | 0.90 | SIGMAR1 (0.54) | DRD2DRD3SIGMAR1ALDH1A1LMNA | |
| SCHEMBL18919203 | 0.89 | PIKFYVE (0.49) | SIGMAR1GPR183POLBMEN1ALDH1A1 | |
| SCHEMBL18919206 | 0.89 | PIKFYVE (0.49) | SIGMAR1GPR183POLBMEN1ALDH1A1 | |
| SCHEMBL18919082 | 0.89 | GPR183 (0.47) | SIGMAR1GPR183MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157135-A1 | FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS | NOVOGEN LIMITED (AU) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170157135-A1 | FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS | TPM3, TPM4, TNNI3 | DRD2 3980/4885DRD3 3690/4885SMPD1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.