Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 6/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 10/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12965946 | 0.80 | MAP3K11 (0.52) | NMT1TNIKDRD2DRD4DRD3 | |
| SCHEMBL18921934 | 0.78 | AXL (0.45) | NMT1TNIKMAP3K11 | |
| SCHEMBL18921935 | 0.78 | MMP3 (0.41) | TNIKPIK3CDMTOR | |
| SCHEMBL18921931 | 0.78 | TNIK (0.42) | NMT1TNIKMTORDRD2DRD4 | |
| SCHEMBL12821617 | 0.78 | TNIK (0.53) | NMT1TNIKPLK4PIK3CDMTOR | |
| SCHEMBL18921930 | 0.76 | HTR6 (0.41) | — | |
| SCHEMBL11992810 | 0.73 | NMT1 (0.49) | NMT1DRD2DRD4DRD3 | |
| SCHEMBL24061116 | 0.71 | MC4R (0.57) | NMT1DRD2 | |
| SCHEMBL31352939 | 0.71 | TNIK (0.80) | TNIKMAP3K11 | |
| SCHEMBL21495134 | 0.71 | MC4R (0.71) | NMT1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962382-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-05-08 | — | — | US | disclosed |
| US-9669028-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2017-06-06 | — | — | US | disclosed |