SCHEMBL18922767

SCHEMBL18922767

COc1ccc(-c2cc(=O)c3c(C=O)cc(OC)cc3o2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 2/20 0.69
MAOB P27338 8/20 0.67
CYP19A1 P11511 1/20 0.67
ALDH1A1 P00352 6/20 0.62
MEN1 O00255 4/20 0.62
KMT2A Q03164 4/20 0.62
MAPT P10636 7/20 0.61
NPC1 O15118 6/20 0.61
CYP3A4 P08684 6/20 0.61
RAB9A P51151 5/20 0.61
SMN1; SMN2 Q16637 5/20 0.61
FLT3 P36888 4/20 0.61
TP53 P04637 4/20 0.61
LMNA P02545 3/20 0.61
IP6K2 Q9UHH9 2/20 0.61
MAOA P21397 2/20 0.61
KCNA5 P22460 2/20 0.61
KCNH2 Q12809 2/20 0.61
CYP2C9 P11712 2/20 0.61
CYP2C19 P33261 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18922798 0.91 ABCG2 (0.70) ABCB1MAOBCYP19A1ALDH1A1MEN1
SCHEMBL24951027 0.87 ABCB1 (0.64) ABCB1MAOBCYP19A1ALDH1A1MEN1
SCHEMBL16623939 0.84 ALDH1A1 (0.66) ABCB1MAOBCYP19A1ALDH1A1MEN1
Trimethylapigenin SCHEMBL1421585 0.82 ABCB1 (1.00) ABCB1MAOBCYP19A1ALDH1A1MEN1
Trimethylapigenin SCHEMBL29350875 0.82 ABCB1 (1.00) ABCB1MAOBCYP19A1ALDH1A1MEN1
Apigenin Dimethylether SCHEMBL29392759 0.81 MAOB (1.00) ABCB1MAOBCYP19A1ALDH1A1MEN1
Apigenin Dimethylether SCHEMBL1176691 0.81 MAOB (1.00) ABCB1MAOBCYP19A1ALDH1A1MEN1
SCHEMBL21981343 0.79 ALDH1A1 (0.65) ABCB1ALDH1A1MEN1KMT2AMAPT
SCHEMBL20664412 0.77 ADORA3 (0.76) ABCB1MAOBCYP19A1ALDH1A1MEN1
Tetramethylscutellarein SCHEMBL739115 0.77 MEN1 (1.00) ABCB1MAOBCYP19A1ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9669066-B2 Use of kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) 2017-06-06 US disclosed