Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.42 |
| ▸ | TUBB | P07437 | 4/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115552 | 0.86 | MAPT (0.56) | MAPTL3MBTL1MAPK1TUBB4ATUBB | |
| SCHEMBL14495329 | 0.85 | TSHR (0.47) | TSHRAPOBEC3AHTTAPOBEC3GMAPT | |
| SCHEMBL1613430 | 0.80 | MGAM (0.41) | TSHRMAPTL3MBTL1HPGDNPSR1 | |
| SCHEMBL31063360 | 0.80 | CA2 (0.38) | TSHRAPOBEC3AHTTAPOBEC3GMAPT | |
| SCHEMBL571771 | 0.80 | TSHR (0.54) | TSHRAPOBEC3AHTTAPOBEC3GMAPT | |
| SCHEMBL571770 | 0.80 | TSHR (0.54) | TSHRAPOBEC3AHTTAPOBEC3GMAPT | |
| SCHEMBL11758295 | 0.79 | MAPT (0.54) | MAPTL3MBTL1ALDH1A1MAPK1TUBB4A | |
| SCHEMBL6948270 | 0.78 | CNR2 (0.55) | TSHRAPOBEC3AHTTAPOBEC3GMAPT | |
| SCHEMBL24386160 | 0.78 | MAPT (0.45) | MAPTL3MBTL1TUBB4ATUBBTUBA3C | |
| SCHEMBL5693703 | 0.78 | ALDH1A1 (0.46) | MAPTL3MBTL1ALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285774-B1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | YISSUM RES DEV CO (IL) | 2015-02-25 | — | — | EP | disclosed |
| EP-2285774-B1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | YISSUM RES DEV CO (IL) | 2015-02-25 | — | — | EP | disclosed |
| US-8637575-B2 | Modulators of protein kinase signaling | NOVOTYR THERAPEUTICS LTD. (IL) | 2014-01-28 | — | — | US | disclosed |
| US-8637575-B2 | Modulators of protein kinase signaling | NOVOTYR THERAPEUTICS LTD. (IL) | 2014-01-28 | — | — | US | disclosed |
| US-8536227-B2 | — | — | 2013-09-17 | — | — | US | disclosed |
| US-8536227-B2 | — | — | 2013-09-17 | — | — | US | disclosed |
| US-20110105618-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | NOVOTYR THERAPEUTICS LTD. (IL) | 2011-05-05 | — | — | US | disclosed |
| US-20110105618-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | NOVOTYR THERAPEUTICS LTD. (IL) | 2011-05-05 | — | — | US | disclosed |
| WO-2009147682-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | NOVOTYR THERAPEUTICS LTD. (IL) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105618-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | MAP3K20, MAP3K1, MAP3K6 | TSHR 928/4885APOBEC3A 4741/4885HTT 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.