Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.41 |
| ▸ | TUBB | P07437 | 4/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28276198 | 0.89 | CNR2 (0.62) | CNR2SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL6946935 | 0.85 | CNR2 (0.47) | CNR2CHEK2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9719041 | 0.85 | ALDH1A1 (0.51) | CNR2CHEK2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6949771 | 0.85 | CHEK2 (0.48) | CNR2CHEK2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7633199 | 0.81 | TOP2A (0.54) | CNR2SMN1; SMN2KMT2AMAPTLMNA | |
| SCHEMBL1892421 | 0.78 | TSHR (0.49) | MAPTMAPK1TSHRHPGDAPOBEC3A | |
| SCHEMBL18287920 | 0.77 | MAPT (0.56) | CNR2SMN1; SMN2MAPTTSHRTUBB4A | |
| SCHEMBL12113567 | 0.77 | CNR2 (0.54) | CNR2SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL8726011 | 0.77 | CNR2 (0.50) | CNR2SMN1; SMN2MAPTTSHRTUBB4A | |
| SCHEMBL571771 | 0.76 | TSHR (0.54) | CHEK2SMN1; SMN2KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |