Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223944 | 0.81 | ESR1 (0.45) | ALDH1A1CYP2D6ESR1GRNSORT1 | |
| SCHEMBL19415197 | 0.80 | KMT2A (0.52) | LTA4HL3MBTL1ALDH1A1LMNACYP2D6 | |
| SCHEMBL14903592 | 0.78 | ESR1 (0.42) | L3MBTL1ALDH1A1LMNACYP2D6MAPT | |
| SCHEMBL19891694 | 0.77 | ESR1 (0.38) | ALDH1A1CYP2D6ESR1 | |
| SCHEMBL6547275 | 0.77 | CALM1 (0.57) | LTA4HALDH1A1LMNACYP2D6TRPA1 | |
| SCHEMBL5109065 | 0.77 | FYN (0.52) | LTA4HL3MBTL1ALDH1A1HTR2BCYP11B1 | |
| SCHEMBL12776135 | 0.77 | ESR1 (0.41) | ALDH1A1CYP2D6ESR1 | |
| SCHEMBL7992583 | 0.77 | ALDH1A1 (0.47) | LTA4HL3MBTL1ALDH1A1HTR2BCYP11B1 | |
| SCHEMBL1680538 | 0.77 | LOXL2 (0.48) | LTA4HL3MBTL1ALDH1A1HTR2BCYP11B1 | |
| SCHEMBL27968366 | 0.77 | MAPT (0.49) | LTA4HALDH1A1LMNACYP2D6HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189826-B2 | Heterocyclic compounds and methods of use | MEDIVATION TECHNOLOGIES LLC (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180051013-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES LLC | 2018-02-22 | — | — | US | disclosed |
| US-9670172-B2 | Heterocyclic compounds and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2017-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189826-B2 | Heterocyclic compounds and methods of use | HRAS, VHL, ESRRB | LTA4H 1446/4885L3MBTL1 3334/4885ALDH1A1 2384/4885 |
| US-20180051013-A1 | Heterocyclic Compounds and Methods of Use | HRAS, VHL, ESRRB | LTA4H 1446/4885L3MBTL1 3334/4885ALDH1A1 2384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.