Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23517941 | 0.83 | CHRNB2 (0.33) | SMN1; SMN2GAAMAPK1NR1H3CHRNB2 | |
| SCHEMBL3932127 | 0.81 | CHRNB2 (0.52) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL9357927 | 0.79 | ALDH1A1 (0.42) | GAAALDH1A1CHRNB2CHRNA4L3MBTL1 | |
| SCHEMBL12988859 | 0.79 | TSHR (0.45) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL28481183 | 0.78 | TSHR (0.37) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL12987849 | 0.77 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3CHRM2 | |
| SCHEMBL20697575 | 0.77 | TSHR (0.43) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL20165974 | 0.77 | TSHR (0.36) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL23436678 | 0.76 | TSHR (0.42) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL6440136 | 0.76 | TSHR (0.42) | TSHRSMN1; SMN2GAAMAPK1NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723728-B2 | Prodrugs of Nh-acidic compounds | ALKERMES PHARMA IRELAND LIMITED (IE) | 2020-07-28 | — | — | US | disclosed |
| US-9670200-B2 | Quaternary ammonium salt prodrugs | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723728-B2 | Prodrugs of Nh-acidic compounds | SI, NAAA, NIT2 | TSHR 3738/4885SMN1; SMN2 606/4885GAA 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.