Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.44 |
| ▸ | CCNC | P24863 | 3/20 | 0.42 |
| ▸ | CDK8 | P49336 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18927575 | 0.86 | RIPK1 (0.59) | RIPK1CCNCCDK8SCD5 | |
| SCHEMBL18927446 | 0.82 | RIPK1 (0.50) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL24133812 | 0.76 | RIPK1 (0.74) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL17747356 | 0.74 | RIPK1 (0.51) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL18406185 | 0.74 | RIPK1 (0.51) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL17454945 | 0.74 | CCNC (0.52) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL28149188 | 0.73 | TRPA1 (0.53) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL18927531 | 0.73 | CCNC (0.42) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL17142311 | 0.72 | TRPA1 (0.51) | RIPK1CCNCCDK8TRPA1ROCK2 | |
| SCHEMBL17453076 | 0.70 | CCNC (0.49) | RIPK1CCNCCDK8TRPA1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096301-A1 | ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1) | DENALI THERAPEUTICS INC. (US) | 2017-06-08 | — | — | WO | disclosed |