Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453074 | 0.87 | RIPK1 (0.48) | CCNCCDK8RIPK1ADAM17ROCK2 | |
| SCHEMBL17453078 | 0.85 | RIPK1 (0.47) | CCNCCDK8RIPK1SCD5ADAM17 | |
| SCHEMBL17453070 | 0.85 | HSD11B1 (0.51) | CCNCCDK8RIPK1ADAM17ROCK2 | |
| SCHEMBL14252999 | 0.85 | RIPK1 (0.64) | RIPK1SCD5ADAM17 | |
| SCHEMBL17453077 | 0.85 | RIPK1 (0.64) | RIPK1SCD5ADAM17 | |
| SCHEMBL17454945 | 0.83 | CCNC (0.52) | CCNCCDK8RIPK1TRPA1SCD5 | |
| SCHEMBL28149188 | 0.83 | TRPA1 (0.53) | CCNCCDK8RIPK1TRPA1SCD5 | |
| SCHEMBL17142311 | 0.81 | TRPA1 (0.51) | CCNCCDK8RIPK1TRPA1SCD5 | |
| SCHEMBL24133812 | 0.79 | RIPK1 (0.74) | CCNCCDK8RIPK1TRPA1SCD5 | |
| SCHEMBL24366083 | 0.78 | CCNC (0.49) | CCNCCDK8RIPK1TRPA1SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | CDK8, CDK9, CDK18 | CCNC 31/4885CDK8 1/4885RIPK1 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.