Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18927447 | 0.86 | RIPK1 (0.44) | RIPK1SCD5CCNCCDK8 | |
| SCHEMBL23139723 | 0.82 | RIPK1 (0.43) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18927573 | 0.81 | RIPK1 (0.61) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18927572 | 0.77 | RIPK1 (0.59) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20011760 | 0.76 | CFB (0.43) | RIPK1PRMT5WDR77 | |
| SCHEMBL18927592 | 0.75 | RIPK1 (0.56) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL12935925 | 0.75 | RIPK1 (1.00) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL17881895 | 0.74 | RIPK1 (0.84) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL17881977 | 0.74 | RIPK1 (0.84) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18927591 | 0.74 | RIPK1 (0.55) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096301-A1 | ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1) | DENALI THERAPEUTICS INC. (US) | 2017-06-08 | — | — | WO | disclosed |