Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16400851 | 0.79 | CFB (0.46) | CFBRIPK1DPP4KDM1A | |
| SCHEMBL16409384 | 0.79 | RIPK1 (0.44) | CFBRIPK1 | |
| SCHEMBL18927575 | 0.76 | RIPK1 (0.59) | RIPK1PRMT5WDR77 | |
| SCHEMBL28858375 | 0.73 | CFB (0.58) | CFBRIPK1KDM1A | |
| SCHEMBL28065026 | 0.72 | RIPK1 (0.44) | CFBRIPK1KDM1A | |
| SCHEMBL23139723 | 0.66 | RIPK1 (0.43) | RIPK1DPP4DPP7 | |
| SCHEMBL23073833 | 0.66 | DPP4 (0.35) | DPP4 | |
| SCHEMBL18927447 | 0.64 | RIPK1 (0.44) | RIPK1DPP4 | |
| SCHEMBL18927572 | 0.64 | RIPK1 (0.59) | RIPK1DPP4 | |
| SCHEMBL2706444 | 0.64 | RIPK1 (0.48) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299365-A1 | PIPERIDINYL-INDOLE DERIVATIVES COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |