Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17207259 | 0.71 | RAB9A (0.42) | KDM4ELMNASMN1; SMN2PIK3C3ALDH1A1 | |
| SCHEMBL30498947 | 0.71 | RAB9A (0.42) | KDM4ELMNASMN1; SMN2PIK3C3ALDH1A1 | |
| SCHEMBL11673448 | 0.71 | CYP2D6 (0.54) | KDM4ELMNACYP3A4TSHRCYP2D6 | |
| SCHEMBL27474726 | 0.70 | KDM4E (0.50) | KDM4ELMNACYP3A4TSHRALDH1A1 | |
| SCHEMBL10273896 | 0.70 | NPC1 (0.66) | KDM4ELMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL29951723 | 0.69 | KDM4E (0.49) | KDM4ELMNACYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL7426398 | 0.69 | KDM4E (0.49) | KDM4ELMNACYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL487201 | 0.69 | KDM4E (0.56) | KDM4ELMNACYP3A4TSHRALDH1A1 | |
| SCHEMBL22221305 | 0.69 | ALDH1A1 (0.56) | KDM4ELMNASMN1; SMN2PIK3C3ALDH1A1 | |
| Iodide SCHEMBL26666900 | 0.69 | CTSS (0.54) | CYP2D6PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |