Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454261 | 0.86 | SCN10A (0.40) | NNMTTYK2JAK2JAK1JAK3 | |
| SCHEMBL31278662 | 0.86 | SCN10A (0.40) | NNMTTYK2JAK2JAK1JAK3 | |
| SCHEMBL30392436 | 0.82 | NNMT (0.47) | NNMTTYK2JAK2JAK1JAK3 | |
| SCHEMBL15688822 | 0.82 | NNMT (0.47) | NNMTTYK2JAK2JAK1JAK3 | |
| SCHEMBL25544448 | 0.82 | CSNK1D (0.43) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL17796856 | 0.81 | NNMT (0.44) | NNMTTYK2JAK2JAK1JAK3 | |
| SCHEMBL26765951 | 0.80 | GABRP (0.38) | NNMTABL1 | |
| SCHEMBL17796149 | 0.80 | SIRT6 (0.39) | NNMTABL1 | |
| SCHEMBL22291639 | 0.79 | USP2 (0.38) | NNMTTYK2JAK2JAK1JAK3 | |
| SCHEMBL29977172 | 0.79 | ABL1 (0.56) | CASP1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |