Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.50 |
| ▸ | STK4 | Q13043 | 4/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21573295 | 0.92 | EGFR (0.55) | EGFRERBB2STK4STK25CIT | |
| SCHEMBL19389768 | 0.86 | EGFR (0.53) | EGFRERBB2STK4 | |
| SCHEMBL18949482 | 0.85 | EGFR (0.60) | EGFRERBB2STK4STK25CIT | |
| SCHEMBL18933434 | 0.85 | EGFR (0.56) | EGFRERBB2STK4STK25CIT | |
| SCHEMBL19389771 | 0.82 | EGFR (0.49) | EGFRERBB2STK4GAK | |
| SCHEMBL18949427 | 0.80 | EGFR (0.58) | EGFRERBB2STK4STK25CIT | |
| SCHEMBL19223046 | 0.80 | EGFR (0.48) | EGFRERBB2STK4STK25CIT | |
| SCHEMBL21573230 | 0.77 | EGFR (0.50) | EGFRERBB2SRCKDR | |
| SCHEMBL18949455 | 0.77 | EGFR (0.64) | EGFRERBB2STK4STK25CIT | |
| SCHEMBL21573263 | 0.75 | EGFR (0.58) | EGFRERBB2STK4STK25CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581372-B1 | CYANOQUINOLINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2017-06-07 | — | — | EP | disclosed |