Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 10/20 | 0.74 |
| ▸ | DAGLB | Q8NCG7 | 7/20 | 0.74 |
| ▸ | DDHD2 | O94830 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18935859 | 0.85 | DAGLA (1.00) | DAGLADAGLBDDHD2 | |
| SCHEMBL18935828 | 0.83 | DAGLA (1.00) | DAGLADAGLBDDHD2 | |
| SCHEMBL18935850 | 0.70 | DAGLA (1.00) | DAGLADAGLBDDHD2 | |
| SCHEMBL18935852 | 0.66 | DAGLA (1.00) | DAGLADAGLBDDHD2 | |
| SCHEMBL7085169 | 0.66 | MTOR (0.46) | ESR1 | |
| SCHEMBL7466231 | 0.65 | L3MBTL3 (0.50) | — | |
| SCHEMBL13503734 | 0.62 | OPRM1 (0.48) | DAGLADAGLBOPRM1PKM | |
| SCHEMBL22901703 | 0.62 | DAGLA (0.63) | DAGLAMGLLTRPV1 | |
| SCHEMBL12204153 | 0.62 | OPRM1 (0.50) | OPRM1PKM | |
| SCHEMBL14668250 | 0.61 | L3MBTL1 (0.63) | OPRM1PKMOPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096315-A1 | TRIAZOLE DAGL(α) INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-08 | — | — | WO | disclosed |