Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18941761 | 0.90 | HPGD (0.51) | HPGDNPC1RAB9ASMN1; SMN2CTSL | |
| SCHEMBL18942207 | 0.90 | HPGD (0.51) | HPGDNPC1RAB9ASMN1; SMN2CTSL | |
| SCHEMBL18941691 | 0.84 | HDAC3 (0.47) | HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18942297 | 0.84 | HPGD (0.43) | HPGDNPC1RAB9ASMN1; SMN2CTSL | |
| SCHEMBL18942222 | 0.84 | KMT2A (0.43) | HPGDNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL18942093 | 0.82 | KMT2A (0.56) | HPGDSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL18942270 | 0.81 | HPGD (0.43) | HPGDNPC1RAB9ASMN1; SMN2CTSL | |
| SCHEMBL18942284 | 0.81 | HPGD (0.55) | HPGDNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL18942112 | 0.81 | MEN1 (0.43) | HPGDNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL18942040 | 0.81 | HPGD (0.54) | HPGDNPC1RAB9ASMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023602-B2 | Hamamelitannin analogues and uses thereof | UNIVERSITEIT GENT (BE) | 2018-07-17 | — | — | US | disclosed |
| US-20170158727-A1 | HAMAMELITANNIN ANALOGUES AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023602-B2 | Hamamelitannin analogues and uses thereof | PIGS, HAMP, HTT | HPGD 190/4885NPC1 3342/4885RAB9A 879/4885 |
| US-20170158727-A1 | HAMAMELITANNIN ANALOGUES AND USES THEREOF | PIGS, HAMP, HTT | HPGD 190/4885NPC1 3342/4885RAB9A 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.