Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18941761 | 0.89 | HPGD (0.51) | HPGDSMN1; SMN2NPC1RAB9AOPRM1 | |
| SCHEMBL18942207 | 0.89 | HPGD (0.51) | HPGDSMN1; SMN2NPC1RAB9AOPRM1 | |
| SCHEMBL18942284 | 0.87 | HPGD (0.55) | HPGDSMN1; SMN2NPC1RAB9AOPRM1 | |
| SCHEMBL18942350 | 0.86 | OPRM1 (0.47) | HPGDOPRM1OPRK1POLBKCNK3 | |
| SCHEMBL18942356 | 0.86 | KDM4E (0.56) | HPGDSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL18941759 | 0.84 | HDAC3 (0.47) | HPGDNPC1RAB9AMAPT | |
| SCHEMBL18942088 | 0.84 | GPR139 (0.45) | HPGDSMN1; SMN2DRD2NPC1RAB9A | |
| SCHEMBL18941691 | 0.83 | HDAC3 (0.47) | HPGDSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL18942259 | 0.83 | OPRM1 (0.46) | HPGDNPC1RAB9AOPRM1OPRK1 | |
| SCHEMBL18942104 | 0.83 | SLC6A2 (0.43) | HPGDSMN1; SMN2NPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023602-B2 | Hamamelitannin analogues and uses thereof | UNIVERSITEIT GENT (BE) | 2018-07-17 | — | — | US | disclosed |
| US-20170158727-A1 | HAMAMELITANNIN ANALOGUES AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023602-B2 | Hamamelitannin analogues and uses thereof | PIGS, HAMP, HTT | HPGD 190/4885SMN1; SMN2 4093/4885DRD2 1456/4885 |
| US-20170158727-A1 | HAMAMELITANNIN ANALOGUES AND USES THEREOF | PIGS, HAMP, HTT | HPGD 190/4885SMN1; SMN2 4093/4885DRD2 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.