Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.49 |
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067426 | 0.84 | AR (0.57) | ESR1ESR2ARCNR2 | |
| SCHEMBL176946 | 0.82 | TRPV4 (0.57) | ESR1ESR2ARTRPV4 | |
| SCHEMBL31122790 | 0.80 | TRPV4 (0.55) | ESR1ESR2ARTRPV4 | |
| SCHEMBL12907061 | 0.79 | AR (0.60) | ESR1ESR2ARCNR2 | |
| SCHEMBL29473510 | 0.78 | CA9 (0.46) | ESR1ESR2ARCA12CA2 | |
| SCHEMBL1697195 | 0.78 | CA9 (0.46) | ESR1ESR2ARCA12CA2 | |
| SCHEMBL2809900 | 0.77 | ESR1 (0.45) | ESR1ESR2ARCA3CA6 | |
| SCHEMBL74807 | 0.76 | TRPV4 (0.46) | ARTRPV4CNR2CA3CA6 | |
| SCHEMBL1267040 | 0.76 | ESR2 (0.44) | ESR1ESR2ARCA12CA2 | |
| Bromide SCHEMBL28616522 | 0.74 | ESR2 (0.43) | ESR1ESR2ARCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109952289-B | TRPV4 antagonists | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2022-12-09 | — | — | CN | claimed |
| CN-109952289-A | TRPV4 antagonist | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2019-06-28 | — | — | CN | claimed |
| EP-0188848-B1 | PREPARATION OF 4-FLUOROPHENOLS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-11-30 | — | — | EP | claimed |
| US-4760160-A | Preparation of 3-cyano-4-fluorophenol | SHELL OIL COMPANY (US) | 1988-07-26 | — | — | US | claimed |
| EP-0188848-A1 | Preparation of 4-fluorophenols | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1986-07-30 | — | — | EP | claimed |
| US-12624051-B2 | Macrocyclic compounds, compositions, and methods of using thereof | GENZYME CORPORATION (US) | 2026-05-12 | — | — | US | disclosed |
| EP-4735423-A1 | KV7 MODULATORS | Saniona A/S (DK) | 2026-05-06 | — | — | EP | disclosed |
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| US-20260062393-A1 | Compounds | CTXT PTY LTD (AU) | 2026-03-05 | — | — | US | disclosed |
| US-20260008785-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SCHRODINGER, LLC | 2026-01-08 | — | — | US | disclosed |
| US-20260008786-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SCHRODINGER, LLC | 2026-01-08 | — | — | US | disclosed |
| EP-4673138-A1 | NBD1 MODULATORS AND METHODS OF USING THE SAME | Sionna Therapeutics Inc. (US) | 2026-01-07 | — | — | EP | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| US-5624601-A | Silacyclohexane compounds, a liquid crystal composition comprising the same and a liquid crystal device comprising the composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| EP-0708107-A1 | Novel silacyclohexane compounds, a liquid crystal composition comprising the same and a liquid crystal device comprising the composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0188848-B1 | PREPARATION OF 4-FLUOROPHENOLS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-11-30 | — | — | EP | disclosed |
| US-4760160-A | Preparation of 3-cyano-4-fluorophenol | SHELL OIL COMPANY (US) | 1988-07-26 | — | — | US | disclosed |
| US-4760160-A | Preparation of 3-cyano-4-fluorophenol | SHELL OIL COMPANY (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0188848-A1 | Preparation of 4-fluorophenols | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1986-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12624051-B2 | Macrocyclic compounds, compositions, and methods of using thereof | CFTR, ABCC3, ABCD3 | ESR1 4028/4885ESR2 3936/4885AR 3579/4885 |
| US-20260008786-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | CFTR, ABCC3, ABCD3 | ESR1 4028/4885ESR2 3936/4885AR 3579/4885 |
| US-20260008785-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | CFTR, ABCC3, ABCD3 | ESR1 3945/4885ESR2 3816/4885AR 3367/4885 |
| US-20260062393-A1 | Compounds | SCN2B, ABCB11, SCN1B | ESR1 2800/4885ESR2 2399/4885AR 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.