Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 6/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18952943 | 0.90 | PTGDR2 (0.37) | PTGDR2MMP13ARHSD11B1HSD11B2 | |
| SCHEMBL30939574 | 0.89 | AR (0.41) | PTGDR2ARHSD11B1HSD11B2CYP11B2 | |
| SCHEMBL1979977 | 0.89 | AR (0.41) | PTGDR2ARHSD11B1HSD11B2CYP11B2 | |
| SCHEMBL18952947 | 0.83 | MMP13 (0.35) | MMP13ARHSD11B1HSD11B2ROCK2 | |
| SCHEMBL18952970 | 0.82 | AR (0.36) | MMP13ARHSD11B1HSD11B2 | |
| SCHEMBL18952954 | 0.82 | MMP13 (0.42) | MMP13AR | |
| SCHEMBL18953024 | 0.82 | AR (0.45) | MMP13ARSCN9AELANE | |
| SCHEMBL30939616 | 0.80 | HSD11B1 (0.38) | PTGDR2ARHSD11B1HSD11B2CYP11B2 | |
| SCHEMBL1979096 | 0.80 | HSD11B1 (0.38) | PTGDR2ARHSD11B1HSD11B2CYP11B2 | |
| SCHEMBL25053757 | 0.80 | PTGDR2 (0.39) | PTGDR2ARHSD11B1CYP11B2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |