Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | OXTR | P30559 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984809 | 0.88 | AR (0.43) | EGLN2TRPV4ARHSD11B1HSD11B2 | |
| SCHEMBL18952970 | 0.85 | AR (0.36) | MMP13TRPV4ARHSD11B1HSD11B2 | |
| SCHEMBL18953024 | 0.84 | AR (0.45) | MMP13ARELANE | |
| SCHEMBL18952995 | 0.83 | PTGDR2 (0.38) | MMP13ARHSD11B1HSD11B2ELANE | |
| SCHEMBL18952979 | 0.80 | MMP13 (0.41) | MMP13AR | |
| SCHEMBL18952974 | 0.79 | MMP13 (0.33) | MMP13TRPV4ARHSD11B1HSD11B2 | |
| SCHEMBL18952943 | 0.78 | PTGDR2 (0.37) | MMP13TRPV4ARHSD11B1HSD11B2 | |
| SCHEMBL13720513 | 0.76 | AR (0.44) | EGLN2AROXTRHSD11B1HSD11B2 | |
| SCHEMBL1979175 | 0.73 | AR (0.44) | ARHSD11B1HSD11B2KDM4EALDH1A1 | |
| SCHEMBL18952976 | 0.73 | HSD11B1 (0.34) | EGLN2TRPV4ARHSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |