Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.78 |
| ▸ | NPC1 | O15118 | 6/20 | 0.78 |
| ▸ | MAPT | P10636 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.69 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.69 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.64 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126415 | 0.93 | PTPN1 (0.87) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL14715824 | 0.91 | NPC1 (0.88) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL18103163 | 0.91 | NPC1 (0.88) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL21646053 | 0.91 | NPC1 (0.72) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL26953087 | 0.89 | PTPN1 (0.88) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL24202631 | 0.89 | SIRT1 (0.83) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| N-Phenylbenzamide SCHEMBL31966 | 0.89 | SIRT1 (0.83) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| N-Phenylbenzamide SCHEMBL5402750 | 0.89 | SIRT1 (0.83) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL82305 | 0.88 | RAB9A (1.00) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL18330583 | 0.87 | PTPN1 (0.77) | RAB9ANPC1MAPTSMN1; SMN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017098421-A1 | BENZOTHIADIAZINE COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |