Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | PARK7 | Q99497 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18954893 | 0.91 | CASP3 (0.41) | CASP3CASP7PARK7ALDH1A1KDM4E | |
| SCHEMBL18954622 | 0.83 | PARK7 (0.48) | CASP3CASP7PARK7ALDH1A1MAPT | |
| SCHEMBL18954627 | 0.79 | ALDH1A1 (0.54) | CASP7ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL15215067 | 0.78 | ALDH1A1 (0.65) | CASP3PARK7ALDH1A1MAPTALDH2 | |
| SCHEMBL18954848 | 0.76 | PARK7 (0.49) | CASP3CASP7PARK7ALDH1A1MAPT | |
| SCHEMBL18954660 | 0.76 | CASP3 (0.57) | CASP3CASP7PARK7ALDH1A1CUL4A | |
| SCHEMBL18954857 | 0.76 | CASP3 (0.54) | CASP3CASP7PARK7ALDH1A1ALDH2 | |
| SCHEMBL18954856 | 0.76 | CASP3 (0.57) | CASP3CASP7PARK7 | |
| SCHEMBL18954711 | 0.75 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10CUL4A | |
| SCHEMBL1519990 | 0.75 | CES1 (0.71) | PARK7ALDH1A1LMNAALDH2ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017099695-A1 | N-[(AMINOSULFONYL)PHENYL]-2-(1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)-HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS | ISTANBUL UNIVERSITESI REKTORLUGU (TR) | 2017-06-15 | — | — | WO | disclosed |