Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665020 | 0.82 | FABP3 (0.38) | MTNR1AMTNR1BFABP3FABP4FABP5 | |
| SCHEMBL3671725 | 0.77 | AR (0.37) | MTNR1AMTNR1BFABP3FABP4FABP5 | |
| Hydrochloric Acid SCHEMBL3664999 | 0.76 | AR (0.36) | MTNR1AMTNR1BFABP3FABP4FABP5 | |
| SCHEMBL12787414 | 0.71 | CYP1A2 (0.58) | TNKS2 | |
| SCHEMBL1896065 | 0.71 | FABP3 (0.38) | MTNR1AFABP3FABP4FABP5SIRT2 | |
| SCHEMBL14445681 | 0.67 | HDAC1 (0.56) | — | |
| SCHEMBL3669718 | 0.66 | FABP3 (0.38) | FABP3FABP4FABP5SIRT2 | |
| SCHEMBL21422363 | 0.65 | KDM4E (0.61) | MTNR1AMTNR1B | |
| SCHEMBL6632237 | 0.65 | RAD52 (0.46) | SIRT2TNKS2 | |
| SCHEMBL2312987 | 0.65 | TAAR1 (0.43) | SIRT2TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056788-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2011-05-12 | — | — | WO | claimed |
| WO-2011056773-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2011-05-12 | — | — | WO | claimed |
| EP-2234960-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | Mayo Foundation for Medical Education and Research (US) | 2010-10-06 | — | — | EP | claimed |
| WO-2009089479-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-07-16 | — | — | WO | claimed |
| WO-2011056788-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2011-05-12 | — | — | WO | disclosed |
| WO-2011056773-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2011-05-12 | — | — | WO | disclosed |
| EP-2234960-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | Mayo Foundation for Medical Education and Research (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009089479-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-07-16 | — | — | WO | disclosed |