SCHEMBL18964307

SCHEMBL18964307

CC(C)(C)OC(=O)NC1CCCN(c2ccc(Cl)cc2F)C1=O

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 14/20 0.53
FPR1 P21462 11/20 0.53
F10 P00742 5/20 0.47
KDM4D Q6B0I6 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23168328 0.88 F10 (0.46) FPR2FPR1F10
SCHEMBL23168331 0.88 F10 (0.46) FPR2FPR1F10
SCHEMBL18955173 0.84 FPR2 (0.57) FPR2FPR1F10
SCHEMBL13958541 0.81 FPR2 (0.40) FPR2FPR1F10
SCHEMBL5710344 0.80 F10 (0.44) FPR2FPR1F10
SCHEMBL5459134 0.80 F10 (0.44) FPR2FPR1F10
SCHEMBL22820700 0.80 FPR2 (0.41) FPR2FPR1F10
SCHEMBL8298724 0.80 F10 (0.51) FPR2FPR1F10
SCHEMBL30133742 0.80 F10 (0.72) FPR2FPR1F10
SCHEMBL30337924 0.80 F10 (0.72) FPR2FPR1F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110996950-B Piperidinone formyl peptide 2 receptor agonists and formyl peptide 1 receptor agonists 百时美施贵宝公司 2023-04-04 CN disclosed
US-11530183-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2022-12-20 US disclosed
US-11530183-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2022-12-20 US disclosed
CN-108368046-B Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists 百时美施贵宝公司 2022-01-14 CN disclosed
US-11186544-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2021-11-30 US disclosed
EP-3414227-B1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-11-24 EP disclosed
US-20200299237-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-09-24 US disclosed
US-10717708-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2020-07-21 US disclosed
US-20200123108-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-04-23 US disclosed
CN-110996950-A Piperidinone formyl peptide 2 receptor agonists and formyl peptide 1 receptor agonists 百时美施贵宝公司 2020-04-10 CN disclosed
WO-2017100390-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2017-06-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10717708-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists FPR1, FPR2, FPR3 FPR2 2/4885FPR1 1/4885F10 2404/4885
US-11186544-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists FPR1, FPR2, FPR3 FPR2 2/4885FPR1 1/4885F10 2461/4885
US-20200123108-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS FPR1, FPR2, FPR3 FPR2 2/4885FPR1 1/4885F10 2461/4885
US-11530183-B2 Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists FPR1, FPR2, FPR3 FPR2 2/4885FPR1 1/4885F10 2404/4885
US-20200299237-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS FPR1, FPR2, FPR3 FPR2 2/4885FPR1 1/4885F10 2404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.