Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 13/20 | 0.56 |
| ▸ | IGF1R | P08069 | 13/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | STK10 | O94804 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | FES | P07332 | 2/20 | 0.52 |
| ▸ | YES1 | P07947 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | ROS1 | P08922 | 2/20 | 0.52 |
| ▸ | FER | P16591 | 2/20 | 0.52 |
| ▸ | LTK | P29376 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | FRK | P42685 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14180580 | 0.95 | INSR (0.52) | INSRIGF1RALKPTK2EGFR | |
| SCHEMBL14180585 | 0.90 | L3MBTL3 (0.51) | INSRIGF1RALKPTK2EGFR | |
| SCHEMBL14180564 | 0.88 | L3MBTL3 (0.54) | INSRIGF1RALKEGFRPLK1 | |
| SCHEMBL12718983 | 0.88 | SIRT6 (0.56) | INSRALKPTK2EGFRNPM1 | |
| SCHEMBL17197436 | 0.86 | TTK (0.52) | INSRIGF1RALKPTK2EGFR | |
| SCHEMBL14180582 | 0.86 | TSHR (0.48) | INSRIGF1RALK | |
| SCHEMBL1911839 | 0.84 | INSR (0.51) | INSRIGF1RALKPTK2EGFR | |
| SCHEMBL14180584 | 0.84 | LRRK2 (0.48) | INSRIGF1RALKPTK2LRRK2 | |
| SCHEMBL19313036 | 0.83 | ALDH1A1 (0.44) | INSRIGF1RALKPTK2EGFR | |
| SCHEMBL517468 | 0.83 | ALK (0.50) | INSRIGF1RALKPTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017097113-A1 | AMINOPYRIMIDINE COMPOUNDS FOR INHIBITING ACITIVITY OF PROTEIN TYROSINE KINASE | 深圳市塔吉瑞生物医药有限公司 | 2017-06-15 | — | — | WO | disclosed |