Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18972807 | 0.85 | MTNR1A (0.46) | RAB9ANPC1EPHX1GAAMAPK1 | |
| SCHEMBL13349453 | 0.85 | MTNR1A (0.46) | RAB9ANPC1EPHX1GAAMAPK1 | |
| SCHEMBL23080984 | 0.85 | MTNR1A (0.46) | RAB9ANPC1EPHX1GAAMAPK1 | |
| SCHEMBL2018813 | 0.84 | — | — | |
| SCHEMBL5022149 | 0.76 | ALDH1A1 (0.41) | RAB9ANPC1EPHX1GAALMNA | |
| SCHEMBL24322791 | 0.76 | LMNA (0.58) | RAB9ANPC1EPHX1LMNASMN1; SMN2 | |
| SCHEMBL14191550 | 0.76 | SMYD3 (0.50) | LMNASMN1; SMN2 | |
| SCHEMBL12820701 | 0.76 | LMNA (0.41) | RAB9ANPC1EPHX1LMNAKDM1A | |
| SCHEMBL12424282 | 0.75 | KMT2A (0.60) | RAB9ANPC1EPHX1GAALMNA | |
| SCHEMBL15014553 | 0.75 | HSD11B1 (0.42) | RAB9ANPC1EPHX1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3719022-A1 | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | Janssen Pharmaceutica NV (BE) | 2020-10-07 | — | — | EP | disclosed |
| EP-3386991-B1 | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2020-06-03 | — | — | EP | disclosed |
| WO-2017100662-A1 | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-15 | — | — | WO | disclosed |