SCHEMBL18985131

SCHEMBL18985131

O=C(Cl)c1ccc(-c2noc(C(F)(F)F)n2)cc1F

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 20/20 0.64
HDAC6 Q9UBN7 14/20 0.64
HDAC1 Q13547 5/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14645825 0.88 HDAC4 (0.65) HDAC4HDAC6HDAC1
SCHEMBL22531083 0.87 HDAC4 (0.70) HDAC4HDAC6HDAC1
SCHEMBL30931870 0.87 HDAC4 (0.70) HDAC4HDAC6HDAC1
SCHEMBL29625964 0.87 HDAC4 (0.64) HDAC4HDAC6HDAC1
SCHEMBL29241997 0.84 HDAC4 (0.60) HDAC4HDAC6HDAC1
SCHEMBL21038624 0.82 HDAC4 (0.76) HDAC4HDAC6HDAC1
SCHEMBL20838193 0.81 HDAC4 (0.68) HDAC4HDAC6HDAC1
SCHEMBL20838025 0.81 HDAC4 (0.68) HDAC4HDAC6HDAC1
SCHEMBL22530593 0.81 HDAC4 (0.64) HDAC4HDAC6HDAC1
SCHEMBL21380548 0.81 HDAC4 (0.69) HDAC4HDAC6HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108779109-B Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2022-03-11 CN disclosed
US-11192867-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-12-07 US disclosed
CN-108368099-B Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2021-11-12 CN disclosed
US-11154060-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-10-26 US disclosed
US-11154060-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-10-26 US disclosed
US-10959432-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-03-30 US disclosed
US-10959432-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-03-30 US disclosed
EP-3464251-B1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-03-03 EP disclosed
US-20200267986-A1 Microbiocidal Oxadiazole Derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-27 US disclosed
US-20200267986-A1 Microbiocidal Oxadiazole Derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-27 US disclosed
EP-3390399-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES Syngenta Participations AG (CH) 2018-10-24 EP disclosed
WO-2017207757-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-12-07 WO disclosed
WO-2017198852-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-11-23 WO disclosed
WO-2017198852-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-11-23 WO disclosed
WO-2017174158-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-10-12 WO disclosed
WO-2017174158-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-10-12 WO disclosed
WO-2017157962-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-09-21 WO disclosed
WO-2017157962-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-09-21 WO disclosed
WO-2017102006-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-06-22 WO disclosed
WO-2017102006-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11192867-B2 Microbiocidal oxadiazole derivatives PRF1, NOX1, ARG2 HDAC4 1469/4885HDAC6 611/4885HDAC1 584/4885
US-10959432-B2 Microbiocidal oxadiazole derivatives PRF1, NOX1, ARG1 HDAC4 1487/4885HDAC6 678/4885HDAC1 597/4885
US-11154060-B2 Microbiocidal oxadiazole derivatives MPO, MSR1, NOX3 HDAC4 1387/4885HDAC6 564/4885HDAC1 435/4885
US-20200267986-A1 Microbiocidal Oxadiazole Derivatives PRF1, NOX1, ARG1 HDAC4 1487/4885HDAC6 678/4885HDAC1 597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.