Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003307 | 0.91 | EGFR (0.60) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003313 | 0.90 | SAE1 (0.46) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003362 | 0.84 | RAB9A (0.46) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003358 | 0.84 | EGFR (0.44) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003274 | 0.84 | MMP1 (0.58) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003273 | 0.83 | MEN1 (0.55) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003234 | 0.82 | MAPT (0.69) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL19003461 | 0.82 | EGFR (0.54) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL18985229 | 0.82 | ACACB (0.50) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL18985271 | 0.81 | CA12 (0.54) | MEN1KMT2ALMNANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |