Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12668507 | 0.88 | ALDH1A1 (0.50) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL1897052 | 0.86 | ALDH1A1 (0.46) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL1896783 | 0.82 | GAA (0.48) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL1895133 | 0.75 | CNR1 (0.41) | TMEM97SIGMAR1HSD17B10KMT2ANAMPT | |
| SCHEMBL15709956 | 0.74 | ALDH1A1 (0.50) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL15244603 | 0.74 | ALDH1A1 (0.50) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL15243998 | 0.74 | ALDH1A1 (0.50) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL850932 | 0.72 | ALDH1A1 (0.43) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL850933 | 0.72 | ALDH1A1 (0.43) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 | |
| SCHEMBL850681 | 0.72 | ALDH1A1 (0.43) | ALDH1A1NPSR1KDM4ETMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937643-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-07-13 | — | — | EP | disclosed |
| EP-1937643-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-07-13 | — | — | EP | disclosed |
| US-8779144-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-8779144-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-8779144-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20110118287-A1 | Bicycloheteroaryl Compounds As P2X7 Modulators and Uses Thereof | RENOVIS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-20110118287-A1 | Bicycloheteroaryl Compounds As P2X7 Modulators and Uses Thereof | RENOVIS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-20110118287-A1 | Bicycloheteroaryl Compounds As P2X7 Modulators and Uses Thereof | RENOVIS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| EP-1937643-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007109160-A9 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS INC (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007109160-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118287-A1 | Bicycloheteroaryl Compounds As P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX1 | ALDH1A1 3160/4885NPSR1 292/4885PARP1 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.