Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18994458 | 0.76 | OPRL1 (0.32) | — | |
| SCHEMBL13819907 | 0.75 | RIPK1 (0.44) | RIPK1 | |
| SCHEMBL18994365 | 0.75 | NUDT1 (0.35) | — | |
| SCHEMBL13028821 | 0.68 | LMNA (0.42) | — | |
| SCHEMBL17029329 | 0.62 | OPRL1 (0.41) | — | |
| SCHEMBL22493345 | 0.62 | OPRL1 (0.43) | HTR1AADRA1A | |
| SCHEMBL11865375 | 0.61 | NMT1 (0.37) | HTR1A | |
| SCHEMBL13827596 | 0.60 | GRM5 (0.41) | HTR1A | |
| SCHEMBL29300678 | 0.60 | OPRL1 (0.40) | RIPK1 | |
| SCHEMBL24350922 | 0.59 | CHRM4 (0.51) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682998-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2017-06-20 | — | — | US | disclosed |