Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21171249 | 0.82 | OPRK1 (0.44) | OPRK1SSTR4 | |
| SCHEMBL20045330 | 0.80 | OPRK1 (0.46) | OPRK1CNR2 | |
| SCHEMBL16944572 | 0.80 | OPRK1 (0.63) | OPRK1 | |
| SCHEMBL2418069 | 0.79 | EPHX2 (0.56) | CNR2 | |
| SCHEMBL3953284 | 0.79 | KDM4E (0.48) | CNR2 | |
| SCHEMBL3824884 | 0.78 | POLB (0.46) | OPRK1AKT2KCNH2RPS6KB1AKT1 | |
| SCHEMBL22907106 | 0.76 | OPRK1 (0.37) | OPRK1ARSSTR4RPS6KB1 | |
| SCHEMBL29631786 | 0.75 | HSD11B1 (0.46) | OPRK1 | |
| SCHEMBL1349136 | 0.74 | EPHX2 (0.64) | FLT3PRKCAGSK3BPRKCQ | |
| SCHEMBL4499593 | 0.72 | SMN1; SMN2 (0.46) | AKT2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | SCRIPPS RESEARCH INST (US) | 2018-04-12 | — | — | US | disclosed |
| US-9682966-B2 | Kappa opioid ligands | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | OPRK1, OPRD1, OPRL1 | FLT3 4358/4885KIT 3559/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.